Pharmacological activities of brown seaweed Sargassum wightii (Family Sargassaceae) using different in vitro models

Anusree, M and Chakraborty, Kajal and Makkar, Fasina (2017) Pharmacological activities of brown seaweed Sargassum wightii (Family Sargassaceae) using different in vitro models. International Journal of Food Properties, 20 (4). pp. 931-945.

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Official URL: http://www.tandfonline.com/doi/full/10.1080/109429...
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    Abstract

    Recently a great deal of interest has been developed towards natural bioactive components from seaweeds as functional food ingredients. Antioxidant, anti-inflammatory, antidiabetic, and antihypertensive activities of ethyl acetate:methanol and chloroform solvent fractions of the brown seaweed Sargassum wightii were evaluated using different in vitro systems. The ethyl acetate:methanol fraction registered greater Fe2+ ion chelating ability (IC50 0.52 mg/ml), and were effective in stabilizing the 2,2-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid (IC50 0.82 mg/mL), and 1,1-diphenyl-2-picryl hydrazil radicals (IC50 0.32 mg/mL) than those derived from chloroform solvent fractions. The chloroform solvent fraction showed greater angiotensin converting enzyme-I inhibitory activity (IC50 0.084 mg/mL), while the ethyl acetate:methanol fraction exhibited greater anti-COX-1, 2, and 5-LOX (IC50 0.03-0.05 mg/mL) and DPP-4 inhibitory (IC50 ~ 0.013 mg/mL) properties. A significant co-linearity was recorded between target bioactive properties and the electronegative groups appeared in the downfield space of the nuclear magnetic resonance spectra of the ethyl acetate:methanol and chloroform solvent fractions from S. wightii.

    Item Type: Article
    Uncontrolled Keywords: Sargassum wightii, Antioxidant, Anti-inflammatory, Cyclooxygenase, Anti-diabetic, Dipeptidyl peptidase, Antihypertensive, Angiotensin-converting enzyme
    Subjects: Fish Biotechnology > Bioactive compound
    Algae > Seaweed
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 14 Sep 2017 09:22
    Last Modified: 14 Sep 2017 09:22
    URI: http://eprints.cmfri.org.in/id/eprint/12154

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