Pharmacological activities of brown seaweed Sargassum wightii (Family Sargassaceae) using different in vitro models

Anusree, M and Chakraborty, Kajal and Makkar, Fasina (2017) Pharmacological activities of brown seaweed Sargassum wightii (Family Sargassaceae) using different in vitro models. International Journal of Food Properties, 20 (4). pp. 931-945.

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Abstract

Recently a great deal of interest has been developed towards natural bioactive components from seaweeds as functional food ingredients. Antioxidant, anti-inflammatory, antidiabetic, and antihypertensive activities of ethyl acetate:methanol and chloroform solvent fractions of the brown seaweed Sargassum wightii were evaluated using different in vitro systems. The ethyl acetate:methanol fraction registered greater Fe2+ ion chelating ability (IC50 0.52 mg/ml), and were effective in stabilizing the 2,2-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid (IC50 0.82 mg/mL), and 1,1-diphenyl-2-picryl hydrazil radicals (IC50 0.32 mg/mL) than those derived from chloroform solvent fractions. The chloroform solvent fraction showed greater angiotensin converting enzyme-I inhibitory activity (IC50 0.084 mg/mL), while the ethyl acetate:methanol fraction exhibited greater anti-COX-1, 2, and 5-LOX (IC50 0.03-0.05 mg/mL) and DPP-4 inhibitory (IC50 ~ 0.013 mg/mL) properties. A significant co-linearity was recorded between target bioactive properties and the electronegative groups appeared in the downfield space of the nuclear magnetic resonance spectra of the ethyl acetate:methanol and chloroform solvent fractions from S. wightii.

Item Type:	Article
Uncontrolled Keywords:	Sargassum wightii, Antioxidant, Anti-inflammatory, Cyclooxygenase, Anti-diabetic, Dipeptidyl peptidase, Antihypertensive, Angiotensin-converting enzyme
Subjects:	Fish Biotechnology > Bioactive compound Algae > Seaweed
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	14 Sep 2017 09:22
Last Modified:	14 Sep 2017 09:22
URI:	http://eprints.cmfri.org.in/id/eprint/12154

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