Validity of zebrafish and mice models to study hyperlipidemia and its mitigation by seaweed-derived bioactive compounds

Rehman, Saima and Gora, Adnan Hussain and Chandrasekar, S and Ebeneezar, Sanal and Linga Prabu, D (2024) Validity of zebrafish and mice models to study hyperlipidemia and its mitigation by seaweed-derived bioactive compounds. In: Course Manual: ICAR Winter School on Harnessing Recent Advances in High-Value Compound Development and Seaweed Biomass Utilization for Human Well-being: Propelling Atmanirbhar Swastha Bharat and Empowering Farmers 15th February to 06th March 2024. CMFRI Training Manual Series (38). ICAR- Central Marine Fisheries Research Institute, Kochi, pp. 395-409.

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Abstract

Cardiovascular diseases pose a significant global health challenge, claiming over 20 million lives annually. In India, cardiovascular diseases contribute to two-thirds of all recorded deaths, exhibiting a sharp increase over the years. One major risk factor for cardiovascular diseases is hyperlipidemia, characterized by elevated blood lipid levels. Seaweed-derived compounds, rich in polyphenols, sulfated polysaccharides, and other bioactive molecules, have demonstrated antihyperlipidemic effects through various mechanisms. This chapter explores the potential of seaweed-derived bioactive compounds in combating hyperlipidemia, focusing on their mechanisms of action. The use of animal models, especially mice and zebra fish in studying the bioactivity of seaweed-derived compounds is also discussed in detail. We provide an overview of the strengths and limitations of both models in studying the efficacy of seaweed-derived compounds in combating hyperlipidemia. The combined knowledge gained from studying mice and zebra fish models can help in the use of high-value compounds from seaweeds for the health and well-being of humans in the future.

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