Previously undescribed antioxidative azocinyl morpholinone alkaloid from red seaweed Gracilaria opuntia with anti-cyclooxygenase and lipoxygenase properties

Makkar, Fasina and Chakraborty, Kajal (2018) Previously undescribed antioxidative azocinyl morpholinone alkaloid from red seaweed Gracilaria opuntia with anti-cyclooxygenase and lipoxygenase properties. Natural Product Research, 32 (10). pp. 1150-1160. ISSN 1478-6427 (Online)

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Kajal Chakraborty_2018_Natural Product Research_Previously undescribed antioxidative azocinyl morpholinone alkaloid from red seaweed Gracilaria opuntia with anti cyclooxygenase and lipoxygenase activities.pdf
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    Abstract

    In vitro antioxidative and anti-inflammatory bioassay-guided fractionation of the methanol: ethyl acetate crude extract of the thalli of red seaweed Gracilaria opuntia collected from the Gulf of Mannar led to the isolation of a new morpholine alkaloid 3-(2-ethyl-6-((3Z,7Z)-1,2,5,6-tetrahydroazocin-5-yl)hexyl) morpholin- 6-one. The substituted azocinyl morpholinone recorded significant 1,1-diphenyl-2-picryl-hydrazil free radical scavenging activities (IC50 ~ 0.086 mg/mL) compared to the commercially available antioxidants, butylated hydroxyanisole, butylated hydroxytoluene, and α-tocopherol (IC50 > 0.20 mg/mL). The title compound showed greater cyclooxygenase-2 (COX-2) inhibitory activity (IC50 0.84 mg/mL) in conjunction with in vitro 5-lipoxidase inhibitory activity (IC50 0.85 mg/mL) than non-steroidal anti-inflammatory drugs (NSAIDs). The test compound had better selectivity index (COX-1/COX-2 ratio) (1.17 mg/mL) compared to aspirin (0.02 mg/mL), Na salicylate (0.73 mg/mL) and ibuprofen (0.44 mg/mL). The animals challenged with the substituted azocinyl morpholinone significantly mitigated the carrageenan-induced paw edema in time-dependent manner till the end of 6 h.

    Item Type: Article
    Uncontrolled Keywords: Azocinyl morpholinone; red seaweed; Gracilaria opuntia; antioxidative; antiinflammatory; selectivity index
    Subjects: Fish Biotechnology > Bioactive compound
    Algae > Seaweed
    Divisions: CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    Depositing User: Arun Surendran
    Date Deposited: 21 Apr 2018 10:10
    Last Modified: 21 Apr 2018 10:10
    URI: http://eprints.cmfri.org.in/id/eprint/12681

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