Development of Fish Parasite Vaccines in the OMICs Era: Progress and Opportunities

Shivam, Saloni and El-Matbouli, Mansour and Kumar, Gokhlesh (2021) Development of Fish Parasite Vaccines in the OMICs Era: Progress and Opportunities. Vaccines, 9 (2). pp. 1-23. ISSN 1095-8649

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Abstract

Globally, parasites are increasingly being recognized as catastrophic agents in both aquaculture sector and in the wild aquatic habitats leading to an estimated annual loss between 1.05 billion and 9.58 billion USD. The currently available therapeutic and control measures are accompanied by many limitations. Hence, vaccines are recommended as the “only green and effective solution” to address these concerns and protect fish from pathogens. However, vaccine development warrants a better understanding of host–parasite interaction and parasite biology. Currently, only one commercial parasite vaccine is available against the ectoparasite sea lice. Additionally, only a few trials have reported potential vaccine candidates against endoparasites. Transcriptome, genome, and proteomic data at present are available only for a limited number of aquatic parasites. Omics-based interventions can be significant in the identification of suitable vaccine candidates, finally leading to the development of multivalent vaccines for significant protection against parasitic infections in fish. The present review highlights the progress in the immunobiology of pathogenic parasites and the prospects of vaccine development. Finally, an approach for developing a multivalent vaccine for parasitic diseases is presented. Data sources to prepare this review included Pubmed, google scholar, official reports, and websites.

Item Type:	Article
Uncontrolled Keywords:	fish parasites; immune response; omics; vaccines
Subjects:	Fish and Fisheries > Fish Pathology Fish Biotechnology Fish and Fisheries
Divisions:	CMFRI-Karwar CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	11 Dec 2023 11:15
Last Modified:	11 Dec 2023 11:24
URI:	http://eprints.cmfri.org.in/id/eprint/17783

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