Transcriptomic signatures differentiating carrier and dead-end fish hosts of proliferative kidney disease

Kumar, Gokhlesh and Sudhagar, Arun and Shivam, Saloni and Ertl, Reinhard and Saleh, Mona and El-Matbouli, Mansour (2026) Transcriptomic signatures differentiating carrier and dead-end fish hosts of proliferative kidney disease. Frontiers in Cellular and Infection Microbiology, 16. pp. 1-13.

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Abstract

Tetracapsuloides bryosalmonae is the causative agent of proliferative kidney disease (PKD) in salmonids. Brown trout function as a carrier host, while rainbow trout serve as a dead-end host. However, the molecular mechanisms underlying these host-specific differences remain poorly understood. Therefore, in the present study, we aimed to identify host-specific transcriptomic signatures distinguishing carrier and dead- end host. A total of 636 and 1,348 unique transcripts were upregulated and downregulated in the infected kidney of brown trout, respectively. In contrast, 526 and 586 unique transcripts were upregulated and downregulated in the infected kidney of rainbow trout, respectively. The uniquely upregulated transcripts in infected brown trout were mainly associated with cell cycle and mitotic cell cycle–related processes, whereas in infected rainbow trout, they were associated with the regulation of biological quality, intracellular signal transduction, and response to chemical stimulus. Similarly, uniquely downregulated transcripts in infected brown trout were mainly associated with anatomical structure morphogenesis, cellular developmental processes, cell differentiation, animal organ development, and cell surface receptor signaling, whereas in infected rainbow trout, they were associated with transmembrane transport, ion transport, and nervous system development.

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