Sulfated rhamnoglucan heteropolysaccharide of Spirulina platensis attenuates methimazole-induced hypothyroidism in rats

Dhara, Subhajit and Reddy, Sambasiva C and Chakraborty, Kajal and Valluru, Lokanatha and Surabhi, Gangadhar (2024) Sulfated rhamnoglucan heteropolysaccharide of Spirulina platensis attenuates methimazole-induced hypothyroidism in rats. Algal Research, 78. pp. 1-11. ISSN 2211-9264

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Abstract

Ingestion of polysaccharide from microalga-derived ‘super food’ Spirulina as a dietary supplement can benefit human health against several chronic disorders. A sulfated heteropolysaccharide with [→4)-α-GlcAp-(1 → 2)-α-Rhap-(1→] as key structural moiety and [(3 → 1)-6-O-SO3-β-Glcp] (SPP-3) as lateral branch, was obtained from microalga Spirulina platensis. SPP-3 exhibited potential anti-thyroid activities by reducing serum cardiovascular risk indices and protein oxidation and nitration in vital tissues of methimazole (MTZ)-induced hypothyroid rats. Upon treatment with SPP-3 (50 mg/kg BW), hypothyroid biomarkers, such as thyroid stimulating hormone (TSH, 5 μIU mL−1), triiodothyronine (T3, 4.55 ng dL−1) and thyroxine (T4, 4.18 μU dL−1) were significantly recovered in comparison with MTZ-induced hypothyroid rats (7.74 μIU mL−1, 2 ng dL−1, 2.49 μIU mL−1, respectively). The level of serum cardiovascular risk indices (CV-I and II) of diseased rats was significantly reduced following the administration of SPP-3 (lesser than 12 %, p < 0.05) compared to the hypothyroid-induced group of animals (18–21 %). SPP-3 substantially downregulated protein nitration (46–49 %) and oxidation (37–39 %) levels in vital tissues than those exhibited by diseased control (90 and 65 % for protein nitration; 81 and 52 % of protein oxidation). Therefore, the microalgal rhamnoglucan (SPP-3) might be utilized as a promising naturally derived food-based carbohydrate biopolymer for health benefits against hypothyroid disorders.

Item Type:	Article
Uncontrolled Keywords:	Microalga: Polysaccharide; Methimazole-induced hypothyroidism; Anti-thyroid activities
Subjects:	Biochemistry > Bioactive compounds Biochemistry > Biochemical composition Algae
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	12 Feb 2024 05:50
Last Modified:	12 Feb 2024 05:50
URI:	http://eprints.cmfri.org.in/id/eprint/17975

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