Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)

Francis, Prima and Chakraborty, Kajal (2022) Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814). Chemistry and Biodiversity. pp. 1-8.

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Abstract

Two undescribed polyketide-type compounds, thalysiaketide A and thalysiaketide B were isolated from a sponge of marine origin Clathria (Thalysias) vulpina (Lamarck, 1814). Thalysiaketide A exhibited significantly greater inhibitory potential against inflammatory 5-lipoxygenase (IC50 0.87 mM) and cyclooxygense-2 (IC500.93 mM) compared to those displayed by its thalysiaketide B analog (IC501.05 mM). The 5-lipoxygenase inhibitory activity of thalysiaketide A was considerably superior to ibuprofen (standard, IC50>4 mM). Higher degree of polar belongings (topological polar surface area 93.06) in conjunction with relatively lower docking parameters of thalysiaketide A with the aminoacyl residues of cyclooxygense-2 and 5-lipoxygenase (docking score 12.99 and 12.27 kcal/mol, respectively) recognized its prospective anti-inflammatory potential

Item Type:	Article
Uncontrolled Keywords:	Clathria (Thalysias) vulpina (Lamarck, 1814); marine sponge; thalysiaketides; anti-inflammatory activity
Subjects:	Biochemistry Marine Ecosystems > Sponges
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	10 Feb 2022 09:20
Last Modified:	10 Feb 2022 09:20
URI:	http://eprints.cmfri.org.in/id/eprint/15769

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