Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)

Francis, Prima and Chakraborty, Kajal (2022) Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814). Chemistry and Biodiversity. pp. 1-8.

[img] Text
Chemistry and Biodiversity_2022_Kajal Chakraborty.pdf
Restricted to Registered users only

Download (420kB) | Request a copy
Official URL: https://onlinelibrary.wiley.com/doi/10.1002/cbdv.2...

Abstract

Two undescribed polyketide-type compounds, thalysiaketide A and thalysiaketide B were isolated from a sponge of marine origin Clathria (Thalysias) vulpina (Lamarck, 1814). Thalysiaketide A exhibited significantly greater inhibitory potential against inflammatory 5-lipoxygenase (IC50 0.87 mM) and cyclooxygense-2 (IC500.93 mM) compared to those displayed by its thalysiaketide B analog (IC501.05 mM). The 5-lipoxygenase inhibitory activity of thalysiaketide A was considerably superior to ibuprofen (standard, IC50>4 mM). Higher degree of polar belongings (topological polar surface area 93.06) in conjunction with relatively lower docking parameters of thalysiaketide A with the aminoacyl residues of cyclooxygense-2 and 5-lipoxygenase (docking score 12.99 and 12.27 kcal/mol, respectively) recognized its prospective anti-inflammatory potential

Item Type: Article
Uncontrolled Keywords: Clathria (Thalysias) vulpina (Lamarck, 1814); marine sponge; thalysiaketides; anti-inflammatory activity
Subjects: Biochemistry
Marine Ecosystems > Sponges
Divisions: CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User: Arun Surendran
Date Deposited: 10 Feb 2022 09:20
Last Modified: 10 Feb 2022 09:20
URI: http://eprints.cmfri.org.in/id/eprint/15769

Actions (login required)

View Item View Item