Sulfated galactofucan from seaweed Padina tetrastromatica attenuates proteolytic enzyme dipeptidylpeptidase-4: a potential anti-hyperglycemic lead

Antony, Tima and Chakraborty, Kajal and Dhara, Subhajit (2022) Sulfated galactofucan from seaweed Padina tetrastromatica attenuates proteolytic enzyme dipeptidylpeptidase-4: a potential anti-hyperglycemic lead. Natural Product Research. pp. 1-12.

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Abstract

Dipeptidyl-peptidase-4 is a multifunctional ectoenzyme, which is implicated with hyperglycemic pathophysiology. Therefore, dipeptidyl-peptidase-4 inhibitors could be used as an attractive therapeutic strategy in blood-glucose homeostasis to attenuate the pathophysiologies of diabetes. A sulfated galactofucan characterized as [!1)-O-4-sulfonato-a-fucopyranosyl-(2!1)-O-2-sulfonatoa-fucopyranose-(3!] along with a branch of [!1)-6-O-methylb-galactopyranosyl-(4!] unit at the C-4 position of O-2-sulfonatoa-fucopyranose, isolated from the seaweed Padina tetrastromatica, exhibited prospective attenuation property against dipeptidylpeptidase-4 (IC50 0.25 mg mL1). The studied sulfated galactofucan exhibited potential inhibitory properties against carbolytic enzymes a-amylase (IC50 0.98 mg mL1) and a-glucosidase (IC500.87 mg mL1) in comparison with the standard antidiabetic agent acarbose, along with radical scavenging activities. The seaweed-originated galactofucan could be developed as a promising natural therapeutic lead against hyperglycemic disorder.

Item Type:	Article
Uncontrolled Keywords:	Seaweed Padina tetrastromatica; galactofucan; anti-hyperglycemic activity; dipeptidylpeptidase-4 inhibitor
Subjects:	Biochemistry Algae > Seaweed
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	18 Jan 2022 05:32
Last Modified:	18 Jan 2022 05:32
URI:	http://eprints.cmfri.org.in/id/eprint/15690

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