Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme

Chakraborty, Kajal and Shilpa, K P (2022) Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme. Natural Product Research. pp. 1-13.

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Abstract

Angiotensin-I-converting enzyme (ACE) is considered as a major drug target for the treatment of hypertension as it catalyses the production of vasoconstrictor angiotensin II from angiotensin I. ACE inhibitor agents are an effective therapeutic strategy to control high blood pressure. Unprecedented polyether macrolides, marginolide A and B were isolated from the crude extract of marine octopus, Amphioctopus marginatus via bioassay-directed sequential chromatographic fractionation. Marginolide A displayed considerably greater ACE attenuation potential (IC50 0.58 mM) than that exhibited by marginolide B (IC50 0.72 mM). Higher antioxidant properties of marginolide A against the oxidant species (IC50 1 mM) also supported its potential ACE inhibitory activity. Higher polar characteristics along with acceptable hydrophobichydrophilic equilibrium (partition coefficient of octanol-water, log Pow 2–4) revealed the potential anti-hypertensive activities of marginolides. This study recognized the anti-hypertensive properties of marginolides as promising pharmaceutical leads.

Item Type:	Article
Uncontrolled Keywords:	Marine octopus; Amphioctopus marginatus; polyether macrolides; marginolides A-B; antihypertensive; angiotensinconverting enzyme
Subjects:	Molluscan Fisheries > Cephalopods Molluscan Fisheries
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	21 Dec 2021 06:54
Last Modified:	26 Dec 2023 11:37
URI:	http://eprints.cmfri.org.in/id/eprint/15630

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