Polygalacto-fucopyranose from marine alga as a prospective antihypertensive lead

Surabhi, Gangadhar and Dhara, Subhajit and Anusree, M and Chakraborty, Kajal and Valluru, Lokanatha and Reddy, Sambasiva C (2021) Polygalacto-fucopyranose from marine alga as a prospective antihypertensive lead. International Journal of Biological Macromolecules, 183. pp. 589-599.

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Abstract

Consumption of marine alga-based polysaccharides as additional functional foods can endow with health benefits by diminishing the risk of chronic diseases. A polygalacto-fucopyranose characterized as [→1)-2, 4-SO3-α- Fucp-(3 → 1)-{2-SO3-α-Fucp-(3→}] with [(4 → 1)-6-OAc-β-Galp-(4→] side chain isolated from marine alga Sargassum wightii exhibited potential antihypertensive activity. Upon treatment with studied polygalactofucan (50 mg/kg BW), serum hypertension biomarkers troponin-T (1.3 pg/mL), troponin-I (1.2 μg/dL) and angiotensin-II converting enzyme (0.18 pg/mL) were significantly recovered in hypertensive rats compared to disease control. Serum cardiovascular risk indices of diseased rats were significantly decreased (< 10%, p < 0.05) after administration of the studied galactofucan (50 mg/kg BW) related to hypertension group (> 17%), andwere comparable with standard antihypertensive agent telmisartan (8.3–10.2% at 2 mg/kg BW). The studied compound was safe for consumption as obvious from the high LD50 value (>5 g/kg), and could be developed as a prospective functional food ingredient attenuating the pathophysiological attributes causing hypertension-related conditions.

Item Type:	Article
Uncontrolled Keywords:	Sargassum wightii; Polygalacto-fucopyranose; Cadmium chloride-induced hypertension
Subjects:	Fish Biotechnology > Bioactive compound Biochemistry > Bioprospecting Biochemistry Fish Biotechnology Algae
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	09 Jul 2021 06:12
Last Modified:	09 Jul 2021 06:12
URI:	http://eprints.cmfri.org.in/id/eprint/15161

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