Antioxidative oxygenated terpenoids with bioactivities against pro-inflammatory inducible enzymes from Indian squid, Uroteuthis (Photololigo) duvaucelii

Chakraborty, Kajal and Krishnan, Soumya and Joy, Minju (2021) Antioxidative oxygenated terpenoids with bioactivities against pro-inflammatory inducible enzymes from Indian squid, Uroteuthis (Photololigo) duvaucelii. Natural Product Research, 35 (6). pp. 1-12. ISSN 1478-6427 (Online)

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Abstract

Cephalopod squid, Uroteuthis (Photololigo) duvaucelii is consumed as culinary delicacy along the southwest part of Asian continent. Ethyl acetate:methanol extract of U. duvaucelii was chromatographically fractionated to yield C19 furano-norditerpenoid (1) along with irregular C15 sesquiterpenoid (2) and C20 diterpenoid compounds (3). In vitro anti-inflammatory and antioxidant analyses were utilised to evaluate their bio-potentials. The C19 furano-norditerpenoid was reported for significantly effective 2,2-diphenyl-1-picrylhydrazyl radical inhibition (IC50 0.60 mg/mL) than other compounds and α-tocopherol (IC50 ≥ 0.64 mg/mL). The 2,2’-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid inhibition and ferrous ion chelating potentials were higher for compounds 1 and 2 (IC50 ∼ 0.69 and ∼0.84 mg/mL, respectively) compared to α-tocopherol (IC50 0.76–0.95 mg/mL). The studied compounds displayed comparable inhibitory activities with synthetic ibuprofen against pro-inflammatory inducible 5-lipoxygenase (IC50 ∼ 0.92 mg/mL). The lower hydrophobicity and steric variables were directly correlated with their antioxidative and anti-inflammatory properties. The studied compounds could be utilised as natural antioxidants and anti-inflammatory functional food ingredients.

Item Type:	Article
Subjects:	Biochemistry > Bioprospecting Biochemistry > Bioactive compounds Biochemistry Molluscan Fisheries > Cephalopods
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	09 Mar 2021 05:03
Last Modified:	09 Mar 2021 05:03
URI:	http://eprints.cmfri.org.in/id/eprint/14948

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