Marine Microbes as a source of Antimicrobial Compounds

Chakraborty, Kajal and Vinaya, K K and Antony, Tima and Joy, Minju and Sreemol, C K (2018) Marine Microbes as a source of Antimicrobial Compounds. In: Winter School on “Recent advances in bioactive compounds from marine organisms and development of high value products for health management, ICAR-Central Marine Fisheries Research Institute, Kochi.

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Abstract

Microbial natural products that have reached the market without any chemical modifications are a testimony to the remarkable ability of microorganisms to produce druglike small molecules. Although still in clinical trails, a feature example of this is salinosporamide A (NPI-0052), a novel anticancer agent found in the exploration of new marine environments (Fenical et al., 2009). In 2008, over 1000 marine natural products were reported (Blunt et al., 2010). However, out of 19 microbial-derived drugs reported in 2008, no natural products from marine microbes were present, signifying the novelty of their systematic exploration (Ganesan, 2008). Currently, >30 compounds of marine microbial origin are in clinical or preclinical studies for the treatment of different types of cancer (Simmons et al., 2005) clearly demonstrating that marine microorganisms have become an essential resource in the discovery of new antibiotic leads.

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