Angiotensin-I Converting Enzyme Inhibitory Activities of Common Edible Cephalopods and their Antioxidative Effects using different in vitro Models

Chakraborty, Kajal and Joy, Minju and Raola, Vamshi Krishna and Makkar, Fasina (2016) Angiotensin-I Converting Enzyme Inhibitory Activities of Common Edible Cephalopods and their Antioxidative Effects using different in vitro Models. Journal of Food Biochemistry. pp. 1-11. ISSN 1745–4514

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Abstract

Antioxidant and antihypertensive potential of ethyl acetate-methanol (EtOAc-MeOH) extract of cephalopods, Amphioctopus marginatus, Uroteuthis duvaucelii, Sepia pharaonis, Sepiella inermis and Cistopus indicus were evaluated using different in vitro systems. EtOAc-MeOH fractions of S. inermis, A. marinates and C. indicus showed greater ferrous ion chelating ability (IC90 5.01–5.8 mg/mL), and were effective in neutralizing the ABTS (IC90 3.5–4.01 mg/mL), and DPPH radicals (IC90 4.69–5.8 mg/mL). The utilities of deconvolated 1H and 13C-NMR spectroscopy for analyzing the signature peaks and abundance of bioactive functional groups in the extracts of cephalopods were illustrated. The EtOAc-MeOH extract derived from S. inermis showed greater angiotensin-converting enzyme-I (ACE-I) inhibitory activity (IC90 0.45 mg/mL) than other cephalopods (IC90 > 0.50 mg/mL). A significant colinearity was found between the electronegative groups present in the downfield position of NMR spectra vis-à-vis antioxidative and ACE-inhibitory activities of EtOAc-MeOH extracts from C. indicus and S. inermis.

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