Adjuvant studies of cytokines in DNA Vaccine against viral haemorrhagic Septicemia virus (VHSV) of Japanese Flounder, Paralichthys olivaceus

Dhanwanthari, E (2004) Adjuvant studies of cytokines in DNA Vaccine against viral haemorrhagic Septicemia virus (VHSV) of Japanese Flounder, Paralichthys olivaceus. PhD thesis, Tokyo University of Fisheries.

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Abstract

Cytokines are low molecular weight soluble proteins secreted by the cells of the innate and adaptive immunity that mediate many of the functions of these cells. They are often pleotropic and redundant. Viral hemorrhagic septicemia is an infectious viral disease of fish, caused by viral hemorrhagic septicemia virus (VHSV) and is responsible for economic losses in aquaculture farms in Japan and around the world. DNA vaccine has been developed for VHSV, but to sustain the immune response of this DNA vaccine for a long time adjuvant studies are required. In the present study we described the adjuvant studies of IL-I~, IL-8 and JFCC I using VHSV as a model system. We also enumerated the gene expression profile of immune related genes of Japanese flounder kidney cells induced by IL-I~, IL-8 and JFCC I.

Item Type:Thesis (PhD)
Supervisor(s):Tokyo University, Japan
Uncontrolled Keywords:Adjuvant studies; cytokines; DNA; Vaccine; viral haemorrhagic Septicemia virus (VHSV); Japanese Flounder; Paralichthys olivaceus
Subjects:Fish Biotechnology
Theses
Fish Genetics
Divisions:CMFRI-Cochin > Marine Biotechnology
ID Code:7509
Deposited By:Dr. V Mohan
Deposited On:14 Feb 2011 15:28
Last Modified:20 Jan 2014 12:50

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