Purushottama, G B and Venkateswaran, K and Pani Prasad, K and Nalini, P (2009) Bioactivities of extracts from the marine sponge Halichondria panicea. Journal of Venomous Animals and Toxins including Tropical Diseases, 15 (3). pp. 444-459.
In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na+-K+ ATP-ase and Mg++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an immunostimulating effect and all extracts revealed angiogenic activity. The aqueous extract yielded nine bands by SDS-PAGE on 12% gel.
|Uncontrolled Keywords:||toxins; sponges|
|Subjects:||Biochemistry > Bioactive compounds|
Marine Ecosystems > Sponges
|Divisions:||CMFRI-Cochin > Marine Biotechnology|
|Deposited By:||Edwin Joseph|
|Deposited On:||04 Nov 2010 14:42|
|Last Modified:||04 Nov 2010 14:42|
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