Bioactivities of extracts from the marine sponge Halichondria panicea

Purushottama, G B and Venkateswaran, K and Pani Prasad, K and Nalini, P (2009) Bioactivities of extracts from the marine sponge Halichondria panicea. Journal of Venomous Animals and Toxins including Tropical Diseases, 15 (3). pp. 444-459.

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Abstract

In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na+-K+ ATP-ase and Mg++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an immunostimulating effect and all extracts revealed angiogenic activity. The aqueous extract yielded nine bands by SDS-PAGE on 12% gel.

Item Type:Article
Uncontrolled Keywords:toxins; sponges
Subjects:Biochemistry > Bioactive compounds
Marine Ecosystems > Sponges
Divisions:CMFRI-Cochin > Marine Biotechnology
ID Code:6045
Deposited By:Edwin Joseph
Deposited On:04 Nov 2010 14:42
Last Modified:04 Nov 2010 14:42

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