Makkar, Fasina and Chakraborty, Kajal (2017) Antidiabetic and anti-inflammatory potential of sulphated polygalactans from red seaweeds Kappaphycus alvarezii and Gracilaria opuntia. International Journal of Food Properties, 20 (6). pp. 1326-1337.
Antidiabetic and anti inflammatory potential _International Journal of Food Properties_2017_Kajal Chakraborty.pdf
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Antidiabetic and anti-inflammatory potential of sulphated polygalactans isolated from the red seaweeds Kappaphycus alvarezii and Gracilaria opuntia were acquired by employing different in vitro systems. The sulphated galactopyran motif derived from G. opuntia possessed significant antidiabetic properties as identified by α-amylase (IC50 0.04 mg/mL), α-glucosidase (IC50 0.09 mg/mL) and dipeptidyl peptidase-4 (DPP-4, IC50 0.09 mg/mL) inhibitory activities. Based on the detailed nuclear magnetic resonance spectroscopy experiments the sulphated galactopyran motif of G. opuntia was designated as →3)-4-O-sulfonato-(6-O-acetyl)-β-D-galactopyranosyl- (1→4)-3,6-anhydro-(2-O-sulfonato)-α-D-galactopyranosyl-(1→3)-4-O-sulfonato-( 6-O-acetyl)-β-D-xylosyl-(1→3)-4-O-sulfonato-(6-O-acetyl)-β-D-galactopyranosyl-( 1→4)-3,6-anhydro-(2-O-sulfonato)-α-D-galactopyranan, while the one from K. alvarezii was demonstrated to be →4)-4-O-sulfonato-(2-Omethyl)- β-D-galactopyranosyl-(1→4)-3,6-anhydro-(2-O-methyl)-α-D-galactopyranan. The sulphated galactans from G. opuntia showed greater antiinflammatory inhibitory activities as determined by cyclooxygenase-1 (COX-1, IC50 0.01 mg/mL), cyclooxygenase-2 (COX-2, IC50 0.03 mg/mL), and 5-lipoxygenase inhibitory activities (5-LOX, IC50 0.24 mg/mL). This study revealed that the sulfated polygalactan enriched concentrate from G. opuntia can be used as potential therapeutic candidate to suppress the hyperglycemic response in diabetic conditions and inflammatory activity. They can be used to develop functional food ingredient in nutraceutical products.
|Uncontrolled Keywords:||Kappaphycus alvarezii, Gracilaria opuntia, Anti-inflammatory, Cyclooxygenase, Lipoxygenase, Antidiabetic, Dipeptidyl peptidase|
|Subjects:||Fish Biotechnology > Bioactive compound
Algae > Seaweed
|Divisions:||CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI-Kochi > Marine Biotechnology
|Depositing User:||Arun Surendran|
|Date Deposited:||28 Oct 2010 09:47|
|Last Modified:||17 Apr 2017 05:51|
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