Fish models in experimental pharmacology: on the mark or off the mark

Supriya, R H and Reshma, K J and Sreekanth, G B (2022) Fish models in experimental pharmacology: on the mark or off the mark. Current Science, 123 (10). pp. 1199-1206. ISSN 0011-3891

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Abstract

Fish has emerged as an alternative model organism in biomedical research for conducting experimental pharmacological and toxicological studies. As a vertebrate, it shares many conserved physiological and molecular features with humans making it a valuable model for diagnosing, investigating disease states and testing drugs to check toxicity and therapeutic activity against the target. Zebrafish and medaka are mainstream models that are widely employed in pharmaceutical research. This study aims to highlight the probability and potential of fish as an alternative model organism in biomedical research, drug discovery and development. Further, it discusses the limitations of fish models in experimental pharmacological and toxicological studies considering the changes in the residing environment, physiology, metabolism, unpredictable inter-individual variability due to diseases, variable conditioning, and interspecific and intraspecific variability.

Item Type:	Article
Uncontrolled Keywords:	Drug screening; fish; model organism; pharmacology; toxicology
Subjects:	Biochemistry Fish and Fisheries > Fish physiology
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	26 May 2023 08:58
Last Modified:	26 May 2023 08:58
URI:	http://eprints.cmfri.org.in/id/eprint/17038

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