Immunomodulatory effect of sulfated galactofucan from marine macroalga Turbinaria conoides

Dhara, Subhajit and Chakraborty, Kajal (2023) Immunomodulatory effect of sulfated galactofucan from marine macroalga Turbinaria conoides. International Journal of Biological Macromolecules, 238. pp. 1-13. ISSN 1879-0003

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    Abstract

    Sulfated polysaccharides are effective immunostimulating agents by activating several intracellular signaling pathways. A sulfated (1 → 3)/(1 → 4)-linked galactofucan TCP-3 with promising immunomodulatory effects was purified from a marine macroalga Turbinaria conoides. The immune-enhancing potential of TCP-3 (100–400 mg/kg BW) was evaluated on cyclophosphamide-induced immunosuppressed animals by increasing bone marrow cellularity (10–13 cells/femur/mL x 106), α-esterase activity (1200–1700 number of positive cells/4000 BMC), interferon-γ (1.31–1.49 pg/mL), interleukin-2 (3.49–3.99 pg/mL) secretion, and WBC count (> 3000 cells/cu mm). The proliferation of lymphocytes for in vitro and in vivo conditions was enhanced by administering TCP-3 besides regulating the secretion of pro-inflammatory cytokines (interleukin-6/1β/12, tumor necrosis factor-α, transforming growth factor-β), and an inducible isoform of nitric oxide synthase. A promising reduction of viral copy formation was observed by administering TCP-3 (< 2 × 107 number) on SARS CoV-2 (delta variant) induced Vero cells in comparison with the infected group (> 5 × 107 number).

    Item Type: Article
    Uncontrolled Keywords: Sulfated (1 → 3)/(1 → 4)-linked galactofucan; Immunomodulation; Anti-SARS-CoV-2 effect
    Subjects: Algae > Algal nutrition
    Biochemistry > Bioactive compounds
    Biochemistry
    Algae
    Divisions: CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
    Depositing User: Arun Surendran
    Date Deposited: 28 Mar 2023 08:46
    Last Modified: 28 Mar 2023 08:46
    URI: http://eprints.cmfri.org.in/id/eprint/16886

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