Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell Turbinaria decurrens

Thambi, Anjaly and Chakraborty, Kajal (2022) Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell Turbinaria decurrens. Natural Product Research. pp. 1-12. ISSN 1478-6427 (Online)

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    Abstract

    Intertidal triangular sea bell Turbinaria decurrens (Bory de Saint-Vincent) (family Sargassaceae) belongs to one of the largely abundant genus of marine brown alga. Bioactivity-directed chromatographic purification of the organic extract of T. decurrens afforded two new nor-dammarane triterpenoids named as decurrencyclic A-B. Decurrencyclic B showed superior attenuation properties against cyclooxygenase-2 (IC50 13.98 μM) and 5-lipoxygenase (IC50 3.02 μM) in contrast with decurrencyclic A. Decurrencyclic B showed higher inhibition potential against COX-2 than that revealed by the anti-inflammatory agent, ibuprofen (IC50 70.44 μM). The higher selectivity index of decurrencyclics (1.39–1.57) acknowledged their selective attenuation property against inducible cyclooxygenase-2. In-silico molecular modeling analysis of decurrencyclic B with the inflammatory enzymes showed least binding energy of −14.55 kcal mol−1. These reports have proven that decurrencyclic B could be a potential therapeutic lead for use against inflammatory pathogenesis.

    Item Type: Article
    Uncontrolled Keywords: Turbinaria decurrens; triangular sea bell marine macroalga; nor-dammarane triterpenoids decurrencyclic A-B; antiinflammatory activity
    Subjects: Algae > Algal nutrition
    Biochemistry > Biochemical composition
    Biochemistry
    Algae
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 22 Jun 2022 06:14
    Last Modified: 22 Jun 2022 06:14
    URI: http://eprints.cmfri.org.in/id/eprint/15999

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