Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814)

Francis, Prima and Chakraborty, Kajal (2022) Undescribed Anti-Inflammatory Thalysiaketides from Marine Sponge Clathria (Thalysias) vulpina (Lamarck, 1814). Chemistry and Biodiversity. pp. 1-8.

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    Two undescribed polyketide-type compounds, thalysiaketide A and thalysiaketide B were isolated from a sponge of marine origin Clathria (Thalysias) vulpina (Lamarck, 1814). Thalysiaketide A exhibited significantly greater inhibitory potential against inflammatory 5-lipoxygenase (IC50 0.87 mM) and cyclooxygense-2 (IC500.93 mM) compared to those displayed by its thalysiaketide B analog (IC501.05 mM). The 5-lipoxygenase inhibitory activity of thalysiaketide A was considerably superior to ibuprofen (standard, IC50>4 mM). Higher degree of polar belongings (topological polar surface area 93.06) in conjunction with relatively lower docking parameters of thalysiaketide A with the aminoacyl residues of cyclooxygense-2 and 5-lipoxygenase (docking score 12.99 and 12.27 kcal/mol, respectively) recognized its prospective anti-inflammatory potential

    Item Type: Article
    Uncontrolled Keywords: Clathria (Thalysias) vulpina (Lamarck, 1814); marine sponge; thalysiaketides; anti-inflammatory activity
    Subjects: Biochemistry
    Marine Ecosystems > Sponges
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 10 Feb 2022 09:20
    Last Modified: 10 Feb 2022 09:20
    URI: http://eprints.cmfri.org.in/id/eprint/15769

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