Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme

Chakraborty, Kajal and Shilpa, K P (2021) Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme. Natural Product Research. pp. 1-13.

[img] Text
Natural Product Research_2021_Kajal Chakraborty and Shilpa K P.pdf
Restricted to Registered users only

Download (1MB) | Request a copy | Please mail the copy request to cmfrilibrary@gmail.com
Official URL: https://www.tandfonline.com/doi/full/10.1080/14786...
Related URLs:

Abstract

Angiotensin-I-converting enzyme (ACE) is considered as a major drug target for the treatment of hypertension as it catalyses the production of vasoconstrictor angiotensin II from angiotensin I. ACE inhibitor agents are an effective therapeutic strategy to control high blood pressure. Unprecedented polyether macrolides, marginolide A and B were isolated from the crude extract of marine octopus, Amphioctopus marginatus via bioassay-directed sequential chromatographic fractionation. Marginolide A displayed considerably greater ACE attenuation potential (IC50 0.58 mM) than that exhibited by marginolide B (IC50 0.72 mM). Higher antioxidant properties of marginolide A against the oxidant species (IC50 1 mM) also supported its potential ACE inhibitory activity. Higher polar characteristics along with acceptable hydrophobichydrophilic equilibrium (partition coefficient of octanol-water, log Pow 2–4) revealed the potential anti-hypertensive activities of marginolides. This study recognized the anti-hypertensive properties of marginolides as promising pharmaceutical leads.

Item Type: Article
Uncontrolled Keywords: Marine octopus; Amphioctopus marginatus; polyether macrolides; marginolides A-B; antihypertensive; angiotensinconverting enzyme
Subjects: Molluscan Fisheries > Cephalopods
Molluscan Fisheries
Divisions: CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI-Kochi > Marine Biotechnology
Depositing User: Arun Surendran
Date Deposited: 21 Dec 2021 06:54
Last Modified: 28 Nov 2022 04:41
URI: http://eprints.cmfri.org.in/id/eprint/15630

Actions (login required)

View Item View Item