Hyrtioscalaranes A and B, two new scalarane-type sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effec

Chakraborty, Kajal and Francis, Prima (2020) Hyrtioscalaranes A and B, two new scalarane-type sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effec. Natural Product Research. pp. 1-12.

Text Natural product reserach_2020_Kajal Chakraborty_ Hyrtios erectus.pdf Restricted to Registered users only Download (1MB) | Please mail the copy request to cmfrilibrary@gmail.com

Abstract

Two new scalarane-type sesterterpenes, hyrtioscalaranes A and B, were isolated from the organic extract of the Demosponge Hyrtios erectus through extensive chromatographic purification. Hyrtioscalarane A exhibited significantly greater attenuation property against cyclooxygense-2 (IC50 0.83 mM) than that displayed by hyrtioscalarane B (IC50 0.98 mM). The greater selectivity index of hyrtioscalaranes (> 1) than that exhibited by the commercial anti-inflammatory agent ibuprofen (0.43) further supported the higher selectivity of the former towards pro-inflammatory cyclooxygenase-2. Hyrtioscalarane A exhibited greater antioxidant activities as determined by 2,2’-azino-bis(3-ethylbenzothiazoline-6- sulphonic acid) (IC50 0.77 mM) and 2,2-diphenyl-1-picrylhydrazyl (IC50 0.81 mM) free radical quenching properties than those displayed by hyrtioscalarane B (IC50 > 0.83 mM) and the antioxidative agent a-tocopherol (IC50 1.51 mM). The greater binding energy (–14.32 kcal/mol) and docking score (15.22 kcal/mol) of hyrtioscalarane A at the active site of cyclooxygenase-2 along with the higher electronic parameters and balanced hydrophobicity could attribute its potential anti-inflammatory activity.

Item Type:	Article
Uncontrolled Keywords:	Hyrtios erectus; Demospongiae; hyrtioscalaranes A and B; scalaranetype sesterterpene derivatives; anti-inflammatory and antioxidant activity; selectivity index
Subjects:	Biochemistry > Bioactive compounds Biochemistry > Biochemical composition Biochemistry
Divisions:	CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division
Depositing User:	Arun Surendran
Date Deposited:	08 Oct 2021 08:43
Last Modified:	08 Oct 2021 08:43
URI:	http://eprints.cmfri.org.in/id/eprint/15397

Actions (login required)

View Item