Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis-c-pyrone polypropionates attenuate angiotensin-converting enzyme

Chakraborty, Kajal and Francis, Prima (2020) Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis-c-pyrone polypropionates attenuate angiotensin-converting enzyme. Natural Product Research. pp. 1-12.

[img] Text
Natural product research_2020_Kajal Chakraborty_Callypyrones.pdf
Restricted to Registered users only

Download (1MB) | Request a copy | Please mail the copy request to cmfrilibrary@gmail.com
Official URL: https://www.tandfonline.com/doi/abs/10.1080/147864...
Related URLs:

Abstract

Angiotensin I-converting enzyme (ACE) catalyses the biosynthesis of angiotensin II, a potent blood vessel constrictor, from angiotensin I, and ACE inhibitors were recognised as medications for hypertension. Undescribed bis-c-pyrone polypropionate compounds, callypyrones A and B were purified from the organic extract of Callyspongiidae sponge species Callyspongia diffusa by repeated chromatographic purification. Callypyrone A exhibited significantly greater attenuation potential against ACE (IC50 0.48 mM) than that displayed by callypyrone B (IC50 0.57 mM) and showed comparable activity with standard ACE inhibitor captopril (IC50 0.36 mM). Higher electronic parameters of callypyrone A (topological surface area of 108.36) combined with balanced hydrophilic-lipophilic parameter (octanol–water coefficient, log Pow 1.9), as deduced from the structure–activity relationship analyses, could further indicate the improved ligand–receptor interactions resulting in its prospective ACE inhibitory activity. In silico docking analyses of the callypyrones with ACE recorded lowest binding energy (–12.58 kcal mol-1 ) for callypyrone A, which further supported the antihypertensive potential of the compound

Item Type: Article
Uncontrolled Keywords: Callyspongia diffusa; Callyspongiidae; callypyrones A-B; bis-c-pyrone polypropionate; angiotensin-converting enzyme; antihypertensive activity; ligand–receptor interactions
Subjects: Biochemistry > Bioactive compounds
Biochemistry > Biochemical composition
Biochemistry
Divisions: CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI-Kochi > Marine Biotechnology
Depositing User: Arun Surendran
Date Deposited: 07 Oct 2021 08:40
Last Modified: 07 Oct 2021 08:40
URI: http://eprints.cmfri.org.in/id/eprint/15394

Actions (login required)

View Item View Item