Silpa, K P and Chakraborty, Kajal (2021) Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase. Natural Product Research. pp. 1-11.
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2) Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus.pdf Restricted to Registered users only Download (2MB) | Please mail the copy request to cmfrilibrary@gmail.com |
Abstract
Biochemical analysis of secondary metabolites of marine old-woman octopus Cistopus indicus (family Octopodidae) led to the identification of two sixteen-membered spiro-linked macrocyclic bislactones, named as cistobislactone A and cistobislactone B with unprecedented feature of henicos framework, based on extensive spectroscopic analyses. Cistobislactone B exhibited potential inhibition property against arachidonate 5-lipoxygenase (IC50 2.18 mM) than that demonstrated by cistobislactone A (IC50 2.54 mM) and standard non-steroidal anti-inflammatory agent ibuprofen (IC50 4.50 mM) thus signifying the higher anti-inflammatory activity of the cistobislactone B analogue.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cistopus indicus ; Octopodidae ; spiro-linked macrocyclic bislactones ; cistobislactones A-B ; anti-inflammatory ; arachidonate 5-lipoxygenase |
| Subjects: | Fish Genetics |
| Divisions: | CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division Subject Area > CMFRI-Kochi > Marine Biotechnology, Fish Nutrition and Health Division |
| Depositing User: | Mr. Prashanth P K |
| Date Deposited: | 18 Sep 2021 07:21 |
| Last Modified: | 16 Mar 2023 06:06 |
| URI: | http://eprints.cmfri.org.in/id/eprint/15333 |
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