Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase

Silpa, K P and Chakraborty, Kajal (2021) Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new antiinflammatory agents attenuate arachidonate 5-lipoxygenase. Natural Product Research. pp. 1-11.

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Official URL: https://doi.org/10.1080/14786419.2021.1938041
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    Abstract

    Biochemical analysis of secondary metabolites of marine old-woman octopus Cistopus indicus (family Octopodidae) led to the identification of two sixteen-membered spiro-linked macrocyclic bislactones, named as cistobislactone A and cistobislactone B with unprecedented feature of henicos framework, based on extensive spectroscopic analyses. Cistobislactone B exhibited potential inhibition property against arachidonate 5-lipoxygenase (IC50 2.18 mM) than that demonstrated by cistobislactone A (IC50 2.54 mM) and standard non-steroidal anti-inflammatory agent ibuprofen (IC50 4.50 mM) thus signifying the higher anti-inflammatory activity of the cistobislactone B analogue.

    Item Type: Article
    Uncontrolled Keywords: Cistopus indicus ; Octopodidae ; spiro-linked macrocyclic bislactones ; cistobislactones A-B ; anti-inflammatory ; arachidonate 5-lipoxygenase
    Subjects: CMFRI Departments > CMFRI-Kochi > Marine Biotechnology
    CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology

    Fish Genetics
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Mr. Prashanth P K
    Date Deposited: 18 Sep 2021 07:21
    Last Modified: 18 Sep 2021 07:21
    URI: http://eprints.cmfri.org.in/id/eprint/15333

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