Biomedical potential of β-chitosan from cuttlebone of cephalopods

Krishnan, Soumya and Chakraborty, Kajal and Dhara, Subhajit (2021) Biomedical potential of β-chitosan from cuttlebone of cephalopods. Carbohydrate Polymers, 273. pp. 1-9.

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    Polymeric β-chitosan allomorph characterized by parallel arrangement of linear polysaccharide comprised of β-(1 → 4)-linked-D-glucosamine and N-acetyl-D-glucosamine was isolated and characterized from the gladius of Indian Ocean Squid (Uroteuthis duvaucelii) and spineless cuttlefish (Sepiella inermis). The β-chitosan from U. duvaucelii displayed considerably greater attenuation potential against hydroxymethylglutaryl coenzyme-A reductase, dipeptidyl peptidase-4, I converting enzyme, and 5-lipoxygenase (IC50 0.15–0.53 mg mL−1) than those exhibited by α-chitosan of comparable molecular weight. Comparatively lesser conformational rigidity of β-chitin could result in its greater susceptibility to deacetylation (86–87%) contrasted to the α-allomorph (~83%), consequently delivering enhanced functionalities than those exhibited by α-chitosan. Porous β-chitosan scaffolds displayed an average pore size of lesser than 50 μm, and its binding capacity was significantly higher than that exhibited by α-chitosan (p < 0.05). Potential pharmacological activities reinforced by lesser binding affinities and intermolecular energy of β-chitosan with the target enzymes recognized its prospective biomedical applications.

    Item Type: Article
    Uncontrolled Keywords: Polymeric β-chitosan α- and β-chitosan allomorphs ; Pharmacological activities; Porous chitosan scaffolds; Degree of deacetylation; Physicochemical and functional properties
    Subjects: Biochemistry > Bioactive compounds
    Molluscan Fisheries > Cephalopods
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 30 Aug 2021 06:15
    Last Modified: 30 Aug 2021 06:15

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