First report of antioxidant 1H-benzochromenone from muricid gastropod Chicoreus ramosus as dual inhibitors of pro-inflammatory 5-lipoxygenase and carbolytic enzymes

Chakraborty, Kajal and Salas, Soumya (2021) First report of antioxidant 1H-benzochromenone from muricid gastropod Chicoreus ramosus as dual inhibitors of pro-inflammatory 5-lipoxygenase and carbolytic enzymes. Natural Product Research, 35 (12). pp. 1949-1958. ISSN 1478-6427 (Online)

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Abstract

Chromene derivatives with manifold structural framework and pharmacological properties were ubiquitous in the mollusks of marine origin. A previously undescribed 1H-benzochromenone was isolated through bioassay-guided chromatographic purification of the organic extract of the marine gastropod mollusk Chicoreus ramosus. The compound was characterised as 6-(20,20- dimethyl)-30-en-10-yl-10-oxy)-3-hydroxy-1H-benzo[c]chromene- 2(10aH)-one based on integrated spectroscopic analysis. The antioxidant studies by employing the stable free radicals reported that the antioxidant activity (IC50 1.4–1.6 mM) was comparable to a-tocopherol (IC50 1.4–1.7 mM). The attenuating potential of the studied compound against pro-inflammatory 5-lipoxygenase (IC50 2.12 mM) was significantly greater than that exhibited by antiinflammatory drug ibuprofen (IC50 4.4 mM), whereas its inhibitory properties against carbolytic a-amylase (IC50 �0.72 mM) was comparable with that displayed by acarbose (IC50 0.43 mM). The present study recognised the potential of 1H-benzochromenone derivative isolated from C. ramosus as important pharmaceutical lead with anti-diabetic and anti-inflammatory potentials to reduce the risk of hyperglycaemia and inflammatory pathologies.

Item Type: Article
Uncontrolled Keywords: Gastropod mollusk; Chicoreus ramosus; 1Hbenzochromenone derivative; pro-inflammatory 5-lipoxygenase; carbolytic enzymes; anti-diabetic and anti-inflammatory
Subjects: CMFRI Departments > CMFRI-Kochi > Marine Biotechnology
CMFRI > CMFRI-Kochi > Marine Biotechnology
CMFRI-Kochi > Marine Biotechnology
CMFRI-Kochi > Marine Biotechnology

Biochemistry > Bioprospecting
Biochemistry
Molluscan Fisheries > Gastropods
Divisions: CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
CMFRI-Kochi > Marine Biotechnology
Subject Area > CMFRI-Kochi > Marine Biotechnology
Depositing User: Arun Surendran
Date Deposited: 09 Jul 2021 06:03
Last Modified: 09 Jul 2021 06:03
URI: http://eprints.cmfri.org.in/id/eprint/15160

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