Euryfuranyl compounds from edible species of cuttlefish as potential anti-inflammatory leads attenuating NF-κB signaling cascade in lipopolysaccharide-activated macrophages

Chakraborty, Kajal and Krishnan, Soumya and Joy, Minju (2021) Euryfuranyl compounds from edible species of cuttlefish as potential anti-inflammatory leads attenuating NF-κB signaling cascade in lipopolysaccharide-activated macrophages. Bioorganic Chemistry, 114. pp. 1-11.

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    Abstract

    Nuclear factor-kappa B is an inducible transcription element, which was considered as an important regulator of immune functions, and plays a critical role to induce inflammatory reactions. In this study, we have demon- strated the anti-inflammatory potentials of previously undescribed (4 → 13)-abeo-euryfuranyls (1–2) from the spineless cuttlefish Sepiella inermis in lipopolysaccharide-stimulated macrophages. The euryfuranyl bearing (4 → 13)-abeo-euryfuranyl-2-ene-6-hydroxymethyl-propanoate framework (compound 1) displayed prominent inhib- itory effects against pro-inflammatory cyclooxygenase-2 (IC50 0.36 mM) and 5-lipoxygenase (IC50 0.70 mM). Additionally, it suppressed the generation of inducible nitric oxide synthase along with cyclooxygenase-2 and 5- lipoxygenase in lipopolysaccharide-stimulated macrophages. The euryfuranyl analogue (1) down-regulated the mRNA expression of cyclooxygenase-2 and nuclear factor-κB signaling pathway in lipopolysaccharide-activated macrophage cells by hindering the degradation of inhibitor-κB proteins, and transfer of the subunit NF-κB p65 to the nucleus from the cytosol. These results demonstrated that the euryfuranyl analogue could be explored as a promising anti-inflammatory therapeutic lead attenuating nuclear factor-κB signaling cascade.

    Item Type: Article
    Uncontrolled Keywords: Spineless cuttlefish; Sepiella inermis; Euryfuranyl analogues; Anti-inflammatory therapeutic lead; Lipopolysaccharide-stimulated macrophages; Nuclear factor-κB signaling cascade
    Subjects: Biochemistry > Bioprospecting
    Biochemistry > Bioactive compounds
    Biochemistry
    Molluscan Fisheries > Cephalopods
    Fish Biotechnology
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 21 Jun 2021 05:40
    Last Modified: 21 Jun 2021 05:40
    URI: http://eprints.cmfri.org.in/id/eprint/15146

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