Antioxidant drimane‐type sesquiterpenoid from muricid gastropod Chicoreus ramosus attenuates pro‐inflammatory 5‐lipoxygenase and carbolytic enzymes

Chakraborty, Kajal and Salas, Soumya (2019) Antioxidant drimane‐type sesquiterpenoid from muricid gastropod Chicoreus ramosus attenuates pro‐inflammatory 5‐lipoxygenase and carbolytic enzymes. Journal of Food Biochemistry. pp. 1-8. ISSN 1745–4514

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    Abstract

    The muricid gastropod, Chicoreus ramosus, is a nutrient‐enriched food source available along the coastal peninsular of the Indian subcontinent. This study was aimed at bioactivity‐directed chromatographic fractionation of the organic extract of C. ramosus to isolate an unprecedented drimane‐type sesquiterpenoid Ramosane, characterized as 3‐hydroxy‐7,9b‐dimethyl‐5‐methylene‐8‐pentyl‐octahydro‐1H‐cyclopenta[a] naphthalen‐9(2H)‐one. The compound possessed potential antioxidant activities {2, 2′‐diphenyl‐1‐picryl hydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐ sulfonic acid (ABTS) radical scavenging activities of IC50 1.42 mM and 1.72 mM, respectively} and was proportionate with those (IC50 1.39 and 1.69 mM, respectively) exhibited by α‐tocopherol. The studied sesquiterpenoid exhibited potential attenuation property countering the pro‐inflammatory 5‐lipoxygenase (IC50 ~ 4 mM), and its activity was analogous with that exhibited by the anti‐inflammatory ibuprofen (IC50 4.36 mM), whereas its carbolytic α‐amylase activity (IC50 0.96 mM) was commensurate with that displayed by acarbose (IC50 0.43 mM). The isolated metabolite might anticipate as potential naturally derived bioactive constituent in functional food and pharmaceutical applications.

    Item Type: Article
    Uncontrolled Keywords: antioxidant, carbolytic enzymes, Chicoreus ramosus, drimane‐type sesquiterpenoid, gastropod mollusk, health food, Muricidae, pro‐inflammatory 5‐lipoxygenase, Ramosane
    Subjects: Fish Biotechnology > Bioactive compound
    Fish Biotechnology
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 22 Nov 2019 05:09
    Last Modified: 22 Nov 2019 05:09
    URI: http://eprints.cmfri.org.in/id/eprint/13957

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