Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis

Chakraborty, Kajal and Joy, Minju and Chakkalakal, Selsa Jose (2019) Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis. Journal of Food Biochemistry, 43 (3). pp. 1-12.

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    The Asian green mussel, Perna viridis is a nutritious health food in the estuarine and coastal sea beds of the Arabian Sea along the west coast of India. In the present study, bioactivity‐guided purification of the chloroform fraction of the methanolic extract of P. viridis was carried out. The isolated secondary metabolites were characterized by spectroscopic experiments, and their antioxidative/antiinflammatory properties were evaluated. The titled compounds were characterized as 3‐hydroxy‐13‐vinyl‐dodecahydro‐11‐phenanthrenone (1), 4,4,9‐trimethyl‐13‐vinyl‐dodecahydro‐2‐phenanthrenone (2), 11,20‐dihydroxy‐6,6‐dimethyl‐decahydro‐5H‐benzo[h]naphtho[1,2‐c]chromene‐16‐carbaldehyde (3), 16‐acetyl‐20‐hydroxy‐6,6‐dimethyl‐dodecahydro‐5H‐benzo[h]naphtho[1,2‐c]chromen‐12‐one (4), cholest‐5‐en‐3β‐3‐yl‐(30‐hydroxy‐3‐methyl‐36‐methyleneundeca‐30E,34E‐dienoate) (5), and cholest‐5‐en‐3β‐3‐yl‐((E)‐33‐oxooct‐31‐enoate) (6). No significant differences in the antioxidant activities of the compounds with chromene‐16‐carbaldehyde (3) and chromen‐12‐one (4) functionalities (IC50 0.52–0.68 mg/ml) vis‐à‐vis the positive control, α‐tocopherol (IC50 0.65–0.76 mg/ml) were registered. The studied compounds, 1–4, displayed potential antiinflammatory activities against pro‐inflammatory 5‐lipoxygenase (5‐LOX) (IC50 < 1 mg/ml). The balanced hydrophilic–lipophilic properties and lower steric values of the studied compounds, 1–4, were correlated with their bioactive potentials.

    Item Type: Article
    Uncontrolled Keywords: antioxidant, Asian green mussel, health food, Perna viridis, pro‐inflammatory 5‐lipoxygenase
    Subjects: Fish Biotechnology > Bioactive compound
    Molluscan Fisheries > Mussel culture
    Fish Biotechnology
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 09 May 2019 05:44
    Last Modified: 10 May 2019 06:54

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