Antioxidative sulphated polygalactans from marine macroalgae as angiotensin-I converting enzyme inhibitors

Makkar, Fasina and Chakraborty, Kajal (2018) Antioxidative sulphated polygalactans from marine macroalgae as angiotensin-I converting enzyme inhibitors. Natural Product Research, 32 (17). pp. 2100-2106. ISSN 1478-6427 (Online)

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    Abstract

    Antioxidant and antihypertensive potential of the sulphated polygalactans isolated from the marine macroalgae Kappaphycus alvarezii and Gracilaria opuntia were assessed by utilising different in vitro systems. The galactans isolated from K. alvarezii possessed significantly greater antioxidative properties as determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH IC90 0.97 mg/mL) and 2,2′-azino-bis(3-ethylbenzothiazoline-6- sulphonic acid (ABTS.+ IC90 0.72 mg/mL) scavenging activities than those isolated from G. opuntia (DPPH IC90 1.2 mg/mL and ABTS 0.86 mg/mL). The sulphated polygalactan →4)-4-O-sulphonato-(2-O-methyl)-β-Dgalactopyranosyl-( 1→4)-3,6-anhydro-(2-O-methyl)-α-D-galactopyranan from K. alvarezii showed greater angiotensin-I-converting enzyme (ACE) inhibitory activity (IC50 0.02 μg/mL) than →3)-4-O-sulphonato-(6-Oacetyl)- β-D-galactopyranosyl-(1→4)-3,6-anhydro-(2-O-sulphonato)-α- D-galactopyranosyl-(1→3)-4-O-sulphonato-(6-O-acetyl)-β-D-xylosyl- (1→3)-4-O-sulphonato-(6-O-acetyl)-β-D-galactopyranosyl-(1→4)-3,6- anhydro-(2-O-sulphonato)-α-D-galactopyranan motif extracted from G. opuntia (IC50 0.70 μg/mL). Structure activity correlation studies displayed that the ACE inhibitory properties of titled polygalactans were directly proportional to their electronic properties and inversely with the steric and hydrophobic characteristics. Putative ACE inhibitory mechanism of action of sulphated galactans from marine macroalgae corroborated the structure bioactivity correlation analysis.

    Item Type: Article
    Uncontrolled Keywords: Sulphated polygalactan; antioxidant activity; angiotensin-I-converting enzyme; marine macroalgae
    Subjects: Biochemistry > Bioactive compounds
    Biochemistry
    Algae
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 02 Aug 2018 04:15
    Last Modified: 02 Aug 2018 04:15
    URI: http://eprints.cmfri.org.in/id/eprint/12982

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