Changes in serum proteins and immune response in oreochromis mossambicus induced by aflatoxin B

Zacharia, Sherly and Thomas, P C and Paulton, M P (2003) Changes in serum proteins and immune response in oreochromis mossambicus induced by aflatoxin B. Indian Journal of Fisheries, 50 (4). pp. 421-426.

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Abstract

Studies were conducted to evaluate the molecular changes induced by aflatoxin, the most frequently encountered dietary carcinogen in Oreochromis mossambicus. Three sub-lethal test doses of aflatoxin B1 incorporated in feed (1.5, 5.0 and 15.0mg/kg feed) were given to the fishes for a period of 30 days and the changes in serum protein profile were resolved through SDS PAGE at regular intervals. Similarly, the changes in immune responses were also studied. The study revealed significant changes in both protein profile and immune response in the experimental fishes compared to the control, indicating that the toxin exerts its effect even at sublethal levels.

Item Type: Article
Uncontrolled Keywords: Serum protein;immune response;Oreochromis;aflatoxin B
Subjects: Fish and Fisheries
Divisions: CMFRI-Cochin > Physiology and Nutrition Pathology
Subject Areas > CMFRI Brochures > CMFRI-Cochin > Physiology and Nutrition Pathology
Depositing User: Dr. V Mohan
Date Deposited: 11 Mar 2010 10:51
Last Modified: 09 Sep 2015 15:05
URI: http://eprints.cmfri.org.in/id/eprint/120

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