Anti-diabetic and anti-inflammatory activities of commonly available cephalopods

Chakraborty, Kajal and Joy, Minju (2017) Anti-diabetic and anti-inflammatory activities of commonly available cephalopods. International Journal of Food Properties, 20 (7). pp. 1655-1665.

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/1094291...
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    Abstract

    Anti-diabetic and anti-inflammatory activities of ethyl acetate-methanol extracts of cephalopods namely, Amphioctopus marginatus, Urothethis duvauceli, Sepia pharaonis, Sepiella inermis, and Cistopus indicus were evaluated. The ethyl acetate-methanol extracts of C. indicus exhibited significantly greater (p < 0.05) cyclooxygenase inhibition activities (IC90 ~ 1 mg/mL, respectively) compared to other cephalopod species. Likewise, C. indicus displayed greater 5-lipoxygenase inhibitory activity (IC90 1.69 mg/ mL) compared to the other cephalopod species (IC90 > 2 mg/mL) considered in the present study. The solvent extracts derived from the members of the order Octopoda demonstrated fairly good α-amylase inhibitory activity (IC90 ≤ 2.5 mg/mL). Dipeptidyl peptidase-4 inhibitory activity of the ethyl acetate-methanol extract of C. indicus was found to be significantly greater (IC50 2.51 mg/mL) than other species of cephalopods (IC50 3.4–5.4 mg/mL; p < 0.05). The labeling of protons associated with different magnetic environments of the functional groups exhibited in the ethyl acetatemethanol extracts were analyzed by proton nuclear magnetic resonance spectroscopy that supported the in vitro anti-diabetic and anti-inflammatory results. The ethyl acetate-methanol extract of C. indicus and S. inermis displayed greater proton integrals (ΣH) of highly electronegative moieties appeared in the low-field region in the proton nuclear magnetic resonance spectroscopy spectra (C. indicus ΣHδ3.5–4.5 5.34, ΣHδ4.5–6.5 6.41; S. inermis ΣHδ3.5–4.5 6.52, and ΣHδ4.5–6.5 15.39) than other cephalopod species. A significant co-linearity was found between the electronegative groups present in the downfield position of nuclear magnetic resonance spectroscopy spectra vis-à-vis anti-diabetic and anti-inflammatory activities.

    Item Type: Article
    Uncontrolled Keywords: Anti-diabetic activity; Antiinflammatory activity; Cyclooxygenases-2; 5- Lipoxygenase; α-glucosidase; α-amylase; Dipeptidyl peptidase-4; Proton nuclear magnetic resonance spectroscopy
    Subjects: Fish Biotechnology > Bioactive compound
    Biochemistry
    Molluscan Fisheries > Cephalopods
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 01 May 2017 08:35
    Last Modified: 01 May 2017 08:35
    URI: http://eprints.cmfri.org.in/id/eprint/11726

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