Bioactive Potential of Sponge Secondary Metabolites

Rajendran, I (2016) Bioactive Potential of Sponge Secondary Metabolites. In: Marine Sponges: Chemicobiological and Biomedical Applications. Springer, India, pp. 1-24. ISBN 978-81-322-2792-2 (In Press)

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    The advent of spongothymidine and spongouridine from the Caribbean sponge Tethya crypta turned the attraction of chemists toward sponges for their unique and novel compounds which have a broad spectrum of biological activity and anticancer property in particular. They find the candidates for the development of new drug analogues with the expected biological activity. The sponge compounds are having a series of bioactivity broadly classified into three groups, viz., pharmacological activity, antagonizing activities, and antifouling activity. Each group is dealt with the allied bioactivities which were observed on the range of sponge compounds during evaluation studies. The biological activities are grouped depending on their similarity and type of testing. The structural groups of the compounds include terpenoids, alkaloids, heterocycles, acetylenic compounds, steroids, and nucleosides. The uniqueness of the selected compounds derived from sponges with the observed bioactivity is discussed.

    Item Type: Book Section
    Uncontrolled Keywords: Marine natural products; Secondary metabolites; Sponge extracts; Bioprospecting; Pharmacological screening
    Subjects: Biochemistry > Bioactive compounds
    Marine Ecosystems > Sponges
    Divisions: CMFRI-Mandapam
    Depositing User: Dr. V Mohan
    Date Deposited: 13 Jul 2016 08:40
    Last Modified: 13 Jul 2016 08:57

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