Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets

Joy, Minju and Chakraborty, Kajal and Vijayagopal, P (2016) Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets. Journal of Food Biochemistry. pp. 1-10. ISSN 1745–4514

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    Abstract

    Clams occupy a predominant share of the edible bivalve mollusks in the coastal regions, and are important seafood resources. Antioxidant, anti-diabetic, anti-inflammatory and antihypertensive potential of ethyl acetate-methanol (EtOAc-MeOH) extract of bivalve clams, Villorita cyprinoides and Paphia malabarica were evaluated using various in vitro systems. EtOAc-MeOH fraction of P. malabarica demonstrated greater 1, 1-diphenyl-2-picryl-hydrazil (0.76 mg/mL) and 2, 2′-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid (1.27 mg/mL) radical scavenging ability. A greater anti-ACE, anti-COX-2/5-LOX properties (1.11, 0.92 and 1.51 mg/mL, respectively), along with DPP-IV (1.00 mg/mL) and α-glucosidase (1.47 mg/mL) inhibitory activities were recorded in the EtOAc-MeOH fraction of P. malabarica than V. cyprinoides. A significant co-linearity was found between various bioactive properties and the down-fielded electronegative groups present in the 1H-NMR spectra of the crude EtOAc-MeOH fractions of bivalve clams. The current findings showed the importance of the bivalves as potential source of antioxidative leads for use as functional food supplements to combat oxidative stress-induced diseases.

    Item Type: Article
    Uncontrolled Keywords: Comparative Bioactive Properties; Bivalve Clams; Disease Molecular Targets
    Subjects: Molluscan Fisheries > Clam
    Biochemistry > Bioactive compounds
    Divisions: CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI > CMFRI-Kochi > Marine Biotechnology
    CMFRI-Kochi > Marine Biotechnology
    Subject Area > CMFRI-Kochi > Marine Biotechnology
    Depositing User: Arun Surendran
    Date Deposited: 13 May 2016 09:10
    Last Modified: 13 May 2016 09:10
    URI: http://eprints.cmfri.org.in/id/eprint/10794

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